To absorb fat — supersize my lipid droplets
Ira J. Goldberg1 and M. Mahmood Hussain2
1Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, New York, New York, USA.
2Diabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, New York, USA.
Address correspondence to: Ira. J. Goldberg, Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, 345 East 30th Street, New York, New York 10016, USA. Phone: 646.501.0589; Email: Ira.Goldberg@nyulangonemc.org.
Find articles by Goldberg, I. in: JCI | PubMed | Google Scholar
1Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, New York, New York, USA.
2Diabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, New York, USA.
Address correspondence to: Ira. J. Goldberg, Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, 345 East 30th Street, New York, New York 10016, USA. Phone: 646.501.0589; Email: Ira.Goldberg@nyulangonemc.org.
Find articles by Hussain, M. in: JCI | PubMed | Google Scholar
First published December 3, 2018 - More info
J Clin Invest. 2019;129(1):58–59. https://doi.org/10.1172/JCI125318.
Copyright © 2019, American Society for Clinical Investigation
Lipins play important roles in adipogenesis, insulin sensitivity, and gene regulation, and mutations in these genes cause lipodystrophy, myoglobinuria, and inflammatory disorders. While all lipins (lipin 1, 2, and 3) act as phosphatidic acid phosphatase (PAP) enzymes, which are required for triacylglycerol (TAG) synthesis from glycerol 3-phosphate, lipin 1 has been the focus of most of the lipin-related research. In the current issue of the JCI, Zhang et al. show that while lipin 2 and 3 are expendable for the incorporation of dietary fatty acids into triglycerides, lipin 2/3 PAP activity has a critical role in phospholipid homeostasis and chylomicron assembly in enterocytes.
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