Ushering in the cardiac role of Ubiquilin1
Xi Fang, Christa Trexler, and Ju Chen
Department of Medicine, UCSD, La Jolla, California, USA.
Address correspondence to: Ju Chen, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 5025, Mail Code 0613C, La Jolla, California 92093, USA. Phone: 858.822.4276; Email: juchen@ucsd.edu.
Authorship note: XF and CT contributed equally to this work.
Find articles by Fang, X. in: JCI | PubMed | Google Scholar
Department of Medicine, UCSD, La Jolla, California, USA.
Address correspondence to: Ju Chen, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 5025, Mail Code 0613C, La Jolla, California 92093, USA. Phone: 858.822.4276; Email: juchen@ucsd.edu.
Authorship note: XF and CT contributed equally to this work.
Find articles by Trexler, C. in: JCI | PubMed | Google Scholar
Department of Medicine, UCSD, La Jolla, California, USA.
Address correspondence to: Ju Chen, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 5025, Mail Code 0613C, La Jolla, California 92093, USA. Phone: 858.822.4276; Email: juchen@ucsd.edu.
Authorship note: XF and CT contributed equally to this work.
Find articles by Chen, J. in: JCI | PubMed | Google Scholar
First published October 22, 2018 - More info
J Clin Invest. 2018;128(12):5195–5197. https://doi.org/10.1172/JCI124567.
Copyright © 2018, American Society for Clinical Investigation
Protein quality control (PQC) mechanisms are essential for maintaining cardiac function, and alterations in this pathway influence multiple forms of heart disease. Since heart disease is the leading cause of death worldwide, understanding how the delicate balance between protein synthesis and degradation is regulated in the heart demands attention. The study by Hu et al. reveals that the extraproteasomal ubiquitin receptor Ubiquilin1 (Ubqln1) plays an important role in cardiac ubiquitination-proteasome coupling, particularly in response to myocardial ischemia/reperfusion injury, thereby suggesting that this may be a new avenue for therapeutics.
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