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Research Article Free access | 10.1172/JCI1230

Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice.

R E Hunger, C Carnaud, I Vogt, and C Mueller

Department of Pathology, University of Bern, CH-3010 Bern, Switzerland.

Find articles by Hunger, R. in: JCI | PubMed | Google Scholar

Department of Pathology, University of Bern, CH-3010 Bern, Switzerland.

Find articles by Carnaud, C. in: JCI | PubMed | Google Scholar

Department of Pathology, University of Bern, CH-3010 Bern, Switzerland.

Find articles by Vogt, I. in: JCI | PubMed | Google Scholar

Department of Pathology, University of Bern, CH-3010 Bern, Switzerland.

Find articles by Mueller, C. in: JCI | PubMed | Google Scholar

Published March 15, 1998 - More info

Published in Volume 101, Issue 6 on March 15, 1998
J Clin Invest. 1998;101(6):1300–1309. https://doi.org/10.1172/JCI1230.
© 1998 The American Society for Clinical Investigation
Published March 15, 1998 - Version history
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Abstract

Similar to pancreatic islets, submandibular glands are more rapidly infiltrated in female NOD mice than in males. The present comparative analysis of cellular infiltrations in lacrimal glands, however, revealed the opposite finding. At 12 wk of age, approximately 25% of male lacrimal tissue area is infiltrated, whereas age-matched female NOD mice still lack major signs of inflammation. T cells predominate in early stages of invasion, but B cells accumulate promptly in more advanced stages, and ultimately dominate over T cells. Dacryoadenitis is promoted by sex hormones, as suggested by the reduced infiltrations seen in orchidectomized NOD males (P < 0.01). It is also controlled by the local environment provided by the lacrimal tissue. Splenocytes from 4- and 20-wk-old female NOD mice cause massive lesions upon adoptive transfer into NOD male recipients while, conversely, female recipients develop barely any histological sign of infiltration, even after transfer of splenocytes from 20-wk-old donor males. These observations provide strong evidence for a dacryoadenitis-promoting role of male gonadal hormones in NOD mice, a finding that contrasts the known androgen-mediated protective effects on insulitis and submandibulitis in the same strain and on dacryoadenitis in other animal models of Sjögren's syndrome.

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