JAK inhibitors in autoinflammation
Hal M. Hoffman and Lori Broderick
Division of Pediatric Allergy, Immunology and Rheumatology, Rady Children’s Hospital – San Diego, San Diego, California, USA and UCSD, La Jolla, California, USA.
Address correspondence to: Hal M. Hoffman or Lori Broderick, 9500 Gilman Dr., MC 0760, La Jolla, California 92093, USA. Email: hahoffman@ucsd.edu (HMH), lbroderick@ucsd.edu (LB).
Find articles by Hoffman, H. in: JCI | PubMed | Google Scholar
Division of Pediatric Allergy, Immunology and Rheumatology, Rady Children’s Hospital – San Diego, San Diego, California, USA and UCSD, La Jolla, California, USA.
Address correspondence to: Hal M. Hoffman or Lori Broderick, 9500 Gilman Dr., MC 0760, La Jolla, California 92093, USA. Email: hahoffman@ucsd.edu (HMH), lbroderick@ucsd.edu (LB).
Find articles by Broderick, L. in: JCI | PubMed | Google Scholar
First published June 11, 2018 - More info
J Clin Invest. 2018;128(7):2760–2762. https://doi.org/10.1172/JCI121526.
Copyright © 2018, American Society for Clinical Investigation
Interferonopathies are a subset of autoinflammatory disorders with a prominent type I IFN gene signature. Treatment of these patients has been challenging, given the lack of response to common autoinflammatory therapeutics including IL-1 and TNF blockade. JAK inhibitors (Jakinibs) are a family of small-molecule inhibitors that target the JAK/STAT signaling pathway and have shown clinical efficacy, with FDA and European Medicines Agency (EMA) approval for arthritic and myeloproliferative syndromes. Sanchez and colleagues repurposed baricitinib to establish a significant role for JAK inhibition as a novel therapy for patients with interferonopathies, demonstrating the power of translational rare disease research with lifesaving effects.
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Copyright © 2018 American Society for Clinical Investigation
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