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Usage Information

JAK inhibitors in autoinflammation
Hal M. Hoffman, Lori Broderick
Hal M. Hoffman, Lori Broderick
Published June 11, 2018
Citation Information: J Clin Invest. 2018;128(7):2760-2762. https://doi.org/10.1172/JCI121526.
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Commentary

JAK inhibitors in autoinflammation

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Abstract

Interferonopathies are a subset of autoinflammatory disorders with a prominent type I IFN gene signature. Treatment of these patients has been challenging, given the lack of response to common autoinflammatory therapeutics including IL-1 and TNF blockade. JAK inhibitors (Jakinibs) are a family of small-molecule inhibitors that target the JAK/STAT signaling pathway and have shown clinical efficacy, with FDA and European Medicines Agency (EMA) approval for arthritic and myeloproliferative syndromes. Sanchez and colleagues repurposed baricitinib to establish a significant role for JAK inhibition as a novel therapy for patients with interferonopathies, demonstrating the power of translational rare disease research with lifesaving effects.

Authors

Hal M. Hoffman, Lori Broderick

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Usage data is cumulative from July 2024 through July 2025.

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Figure 125 0
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