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Research Article Free access | 10.1172/JCI119892

Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice.

A Nicoletti, S Kaveri, G Caligiuri, J Bariéty, and G K Hansson

Center for Molecular Medicine, Karolinska Institute, S-17176 Stockholm, Sweden.

Find articles by Nicoletti, A. in: JCI | PubMed | Google Scholar

Center for Molecular Medicine, Karolinska Institute, S-17176 Stockholm, Sweden.

Find articles by Kaveri, S. in: JCI | PubMed | Google Scholar

Center for Molecular Medicine, Karolinska Institute, S-17176 Stockholm, Sweden.

Find articles by Caligiuri, G. in: JCI | PubMed | Google Scholar

Center for Molecular Medicine, Karolinska Institute, S-17176 Stockholm, Sweden.

Find articles by Bariéty, J. in: JCI | PubMed | Google Scholar

Center for Molecular Medicine, Karolinska Institute, S-17176 Stockholm, Sweden.

Find articles by Hansson, G. in: JCI | PubMed | Google Scholar

Published September 1, 1998 - More info

Published in Volume 102, Issue 5 on September 1, 1998
J Clin Invest. 1998;102(5):910–918. https://doi.org/10.1172/JCI119892.
© 1998 The American Society for Clinical Investigation
Published September 1, 1998 - Version history
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Abstract

Atherosclerosis is associated with immune activation. T cells and macrophages infiltrate atherosclerotic plaques and disease progression is associated with formation of autoantibodies to oxidized lipoproteins. In the apo E knockout mouse, a genetic model of cholesterol-induced atherosclerosis, congenital deficiency of macrophages, lymphocytes, or interferon-gamma receptors result in reduced lesion formation. We have now evaluated whether immune modulation in the adult animal affects disease development. Injections of 7-wk-old male apo E knockout mice with polyclonal immunoglobulin preparations (ivIg) during a 5-d period reduced fatty streak formation over a 2-mo period on cholesterol diet by 35%. Fibrofatty lesions induced by diet treatment for 4 mo were reduced by 50% in mice receiving ivIg after 2 mo on the diet. ivIg treatment also reduced IgM antibodies to oxidized LDL and led to inactivation of spleen and lymph node T cells. These data indicate that ivIg inhibits atherosclerosis, that it is effective both during the fatty streak and plaque phases, and that it may act by modulating T cell activity and/or antibody production. Therefore, immunomodulation may be an effective way to prevent and/or treat atherosclerosis.

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