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Research Article Free access | 10.1172/JCI118832

Identification of an immunodominant mouse minor histocompatibility antigen (MiHA). T cell response to a single dominant MiHA causes graft-versus-host disease.

C Perreault, J Jutras, D C Roy, J G Filep, and S Brochu

Department of Medicine, University of Montreal, Quebec, Canada. perreauc@ere.umontreal.ca

Find articles by Perreault, C. in: PubMed | Google Scholar

Department of Medicine, University of Montreal, Quebec, Canada. perreauc@ere.umontreal.ca

Find articles by Jutras, J. in: PubMed | Google Scholar

Department of Medicine, University of Montreal, Quebec, Canada. perreauc@ere.umontreal.ca

Find articles by Roy, D. in: PubMed | Google Scholar

Department of Medicine, University of Montreal, Quebec, Canada. perreauc@ere.umontreal.ca

Find articles by Filep, J. in: PubMed | Google Scholar

Department of Medicine, University of Montreal, Quebec, Canada. perreauc@ere.umontreal.ca

Find articles by Brochu, S. in: PubMed | Google Scholar

Published August 1, 1996 - More info

Published in Volume 98, Issue 3 on August 1, 1996
J Clin Invest. 1996;98(3):622–628. https://doi.org/10.1172/JCI118832.
© 1996 The American Society for Clinical Investigation
Published August 1, 1996 - Version history
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Abstract

T cell responses to non-MHC antigens are targeted to a restricted number of immunodominant minor histocompatibility antigens whose identity remains elusive. Here we report isolation and sequencing of a novel immunodominant minor histocompatibility antigen presented by H-2Db on the surface of C57BL/6 mouse cells. This nonapeptide (AAPDNRETF) shows strong biologic activity in cytotoxic T lymphocyte sensitization assays at concentrations as low as 10 pM. C3H.SW mice primed with AAPDNRETF in incomplete Freund's adjuvant generated a potent anti-C57BL/6 T cell-mediated cytotoxic activity, and T lymphocytes from AAPDNRETF-primed mice caused graft-versus-host disease when transplanted in irradiated C57BL/6 recipients. These results (a) provide molecular characterization of a mouse dominant minor histocompatibility antigen, (b) identify this peptide as a potential target of graft-versus-host disease and, (c) more importantly, demonstrate that a single dominant minor antigen can cause graft-versus-host disease. These findings open new avenues for the prevention of graft-versus-host disease and should further our understanding of the mechanisms of immunodominance in T cell responses to minor histocompatibility antigens.

Version history
  • Version 1 (August 1, 1996): No description

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