Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI118552

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

J E Salmon, S Millard, L A Schachter, F C Arnett, E M Ginzler, M F Gourley, R Ramsey-Goldman, M G Peterson, and R P Kimberly

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Salmon, J. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Millard, S. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Schachter, L. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Arnett, F. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Ginzler, E. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Gourley, M. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Ramsey-Goldman, R. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Peterson, M. in: PubMed | Google Scholar

Department of Medicine, Graduate Program in Immunology, The Cornell University Medical College, New York 10021, USA.

Find articles by Kimberly, R. in: PubMed | Google Scholar

Published March 1, 1996 - More info

Published in Volume 97, Issue 5 on March 1, 1996
J Clin Invest. 1996;97(5):1348–1354. https://doi.org/10.1172/JCI118552.
© 1996 The American Society for Clinical Investigation
Published March 1, 1996 - Version history
View PDF
Abstract

Allelic variants of Fc gamma R confer distinct phagocytic capacities providing a mechanism for heritable susceptibility to immune complex disease. Human Fc gamma RIIa has two codominantly expressed alleles, R131 and H131, which differ substantially in their ability to ligate human IgG2. The Fc gamma RIIa-H131 is the only human Fc gamma R which recognizes IgG2 efficiently and optimal IgG2 handling occurs only in the homozygous state. Therefore, since immune complex clearance is essential in SLE, we hypothesized that Fc gamma RIIA genes are important disease susceptibility factors for SLE, particularly lupus nephritis. In a two-stage cross-sectional study, we compared the distribution of Fc gamma RIIA alleles in African Americans with SLE to that in African American non-SLE controls. A pilot study of 43 SLE patients and 39 controls demonstrated a skewed distribution of Fc gamma RIIA alleles, with only 9% of SLE patients homozygous for Fc gamma RIIa-H131 compared with 36% of controls (odds ratio, 0.18; 95% CI, 0.05-0.69, P = 0.009). This was confirmed with a multicenter study of 214 SLE patients and 100 non-SLE controls. The altered distribution of Fc gamma RIIA alleles was most striking in lupus nephritis. Trend analysis of the genotype distribution showed a highly significant decrease in Fc gamma RIIA-H131 as the likelihood for lupus nephritis increased (P = 0.0004) consistent with a protective effect of the Fc gamma RIIA-H131 gene. The skewing in the distribution of Fc gamma RIIA alleles identifies this gene as a risk factor with pathophysiologic importance for the SLE diathesis in African Americans.

Version history
  • Version 1 (March 1, 1996): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts