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Research Article Free access | 10.1172/JCI117759

Telomeric DNA in normal and leukemic blood cells.

O Yamada, K Oshimi, T Motoji, and H Mizoguchi

Department of Hematology, Tokyo Women's Medical College, Japan.

Find articles by Yamada, O. in: PubMed | Google Scholar

Department of Hematology, Tokyo Women's Medical College, Japan.

Find articles by Oshimi, K. in: PubMed | Google Scholar

Department of Hematology, Tokyo Women's Medical College, Japan.

Find articles by Motoji, T. in: PubMed | Google Scholar

Department of Hematology, Tokyo Women's Medical College, Japan.

Find articles by Mizoguchi, H. in: PubMed | Google Scholar

Published March 1, 1995 - More info

Published in Volume 95, Issue 3 on March 1, 1995
J Clin Invest. 1995;95(3):1117–1123. https://doi.org/10.1172/JCI117759.
© 1995 The American Society for Clinical Investigation
Published March 1, 1995 - Version history
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Abstract

We studied telomeric DNA in leukemic cells as well as in normal T cells, B cells, monocytes, polymorphonuclear leukocytes, and bone marrow hematopoietic progenitor cells. No marked differences were observed in the sizes of the telomeric repeats in the various populations of normal blood cells obtained from donors in their twenties to sixties, and the telomere length ranged between 8.5 and 9.0 kb. The leukemic cells of 12 patients with acute leukemia (seven with myeloid and five with lymphoid leukemia) showed a variable reduction in the length of telomeric DNA, ranging from 2.7 to 6.4 kb. The average telomere length was 4.8 and 4.7 kb in myeloid and lymphoid leukemia, respectively, while the telomere length in peripheral blood mononuclear cells obtained from the same patients during complete remission was 8.5 and 7.9 kb, respectively. When the same Southern blots were hybridized with Alu or alphoid sequences, no marked changes in the sizes of the repetitive DNA sequences were observed, indicating that the DNA abnormality in the leukemic cells was specific to the telomere region. Investigation of telomeric DNA changes may be helpful in determining the biological properties of leukemic cells.

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