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Rhesus monkey lipoprotein(a) binds to lysine Sepharose and U937 monocytoid cells less efficiently than human lipoprotein(a). Evidence for the dominant role of kringle 4(37).
A M Scanu, L A Miles, G M Fless, D Pfaffinger, J Eisenbart, E Jackson, J L Hoover-Plow, T Brunck, E F Plow
A M Scanu, L A Miles, G M Fless, D Pfaffinger, J Eisenbart, E Jackson, J L Hoover-Plow, T Brunck, E F Plow
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Research Article

Rhesus monkey lipoprotein(a) binds to lysine Sepharose and U937 monocytoid cells less efficiently than human lipoprotein(a). Evidence for the dominant role of kringle 4(37).

Abstract

Rhesus lipoprotein(a) (Lp[a]) binds less efficiently than human Lp(a) to lysine-Sepharose and to cultured U937 cells. Studies using elastase-derived plasminogen fragments indicated that neither kringle 5 nor the protease domain of Lp(a) are required in these interactions pointing at an involvement of the K4 region. Comparative structural analyses of both the human and simian apo(a) K4 domain, together with molecular modeling studies, supported the conclusion that K4(37) plays a dominant role in the lysine binding function of apo(a) and that the presence of arginine 72 rather than tryptophan in this kringle can account for the functional deficiency observed with rhesus Lp(a). These in vitro results suggest that rhesus Lp(a) may be less thrombogenic than human Lp(a).

Authors

A M Scanu, L A Miles, G M Fless, D Pfaffinger, J Eisenbart, E Jackson, J L Hoover-Plow, T Brunck, E F Plow

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