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Research Article Free access | 10.1172/JCI115849

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

C Baylis, B Mitruka, and A Deng

Department of Physiology, West Virginia University, Morgantown 26506.

Find articles by Baylis, C. in: PubMed | Google Scholar

Department of Physiology, West Virginia University, Morgantown 26506.

Find articles by Mitruka, B. in: PubMed | Google Scholar

Department of Physiology, West Virginia University, Morgantown 26506.

Find articles by Deng, A. in: PubMed | Google Scholar

Published July 1, 1992 - More info

Published in Volume 90, Issue 1 on July 1, 1992
J Clin Invest. 1992;90(1):278–281. https://doi.org/10.1172/JCI115849.
© 1992 The American Society for Clinical Investigation
Published July 1, 1992 - Version history
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Abstract

Tonic basal release of nitric oxide (NO) by vascular endothelial cells controls blood pressure (BP) in the basal state. In these studies we investigated the effects of chronic inhibition of basal NO synthesis in the rat for a 2-mo period. Significant systemic hypertension developed in chronically NO-blocked rats compared to controls. Marked renal vasoconstriction was also observed with elevations in glomerular blood pressure (PGC) and reductions in the glomerular capillary ultrafiltration coefficient (Kf). Chronically NO-blocked rats also develop proteinuria and glomerular sclerotic injury compared to controls. These studies therefore describe a new model of systemic hypertension with glomerular capillary hypertension and renal disease due to chronic blockade of endogenous NO synthesis. These observations highlight the importance of the endogenous NO system in control of normal vascular tone and suggest that hypertensive states may result from relative NO deficiency.

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