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Research Article Free access | 10.1172/JCI115792

Hydrogen ion concentration is not the sole determinant of muscle metaboreceptor responses in humans.

L I Sinoway, R F Rea, T J Mosher, M B Smith, and A L Mark

Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Find articles by Sinoway, L. in: PubMed | Google Scholar

Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Find articles by Rea, R. in: PubMed | Google Scholar

Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Find articles by Mosher, T. in: PubMed | Google Scholar

Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Find articles by Smith, M. in: PubMed | Google Scholar

Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Find articles by Mark, A. in: PubMed | Google Scholar

Published June 1, 1992 - More info

Published in Volume 89, Issue 6 on June 1, 1992
J Clin Invest. 1992;89(6):1875–1884. https://doi.org/10.1172/JCI115792.
© 1992 The American Society for Clinical Investigation
Published June 1, 1992 - Version history
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Abstract

We examined the effects of exercise conditioning on muscle sympathetic nerve activity (MSNA) during handgrip and posthandgrip circulatory arrest (PHG-CA). Two conditioning stimuli were studied: forearm dominance and bodybuilding. Static handgrip at 30% maximal voluntary contraction followed by PHG-CA led to a rise in MSNA smaller in dominant than in nondominant forearms (99% vs. 222%; P less than 0.02) and in body builders than in normal volunteers (28% vs. 244%; P less than 0.01). Separate 31P NMR experiments showed no effect of dominance on forearm pH but a pH in bodybuilders higher (6.88) than in normal volunteers (6.79; P less than 0.02) during PHG-CA. Our second goal was to determine if factors besides attenuated [H+] contribute to this conditioning effect. If differences in MSNA during exercise were noted at the same pH, then other mechanisms must contribute to the training effect. We measured MSNA during ischemic fatiguing handgrip. No dominance or bodybuilding effect on pH was noted. However, we noted increases in MSNA smaller in dominant than nondominant forearms (212% vs. 322%; P less than 0.02) and in bodybuilders than in normal volunteers (161% vs. 334%; P less than 0.01). In summary, MSNA responses were less during exercise of conditioned limbs. Factors aside from a lessening of muscle acidosis contribute to this effect.

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