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Research Article Free access | 10.1172/JCI115711

Conserved mechanism of negative gene regulation by extracellular calcium. Parathyroid hormone gene versus atrial natriuretic polypeptide gene.

T Okazaki, K Ando, T Igarashi, E Ogata, and T Fujita

4th Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

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4th Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

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4th Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

Find articles by Igarashi, T. in: PubMed | Google Scholar

4th Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

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4th Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

Find articles by Fujita, T. in: PubMed | Google Scholar

Published April 1, 1992 - More info

Published in Volume 89, Issue 4 on April 1, 1992
J Clin Invest. 1992;89(4):1268–1273. https://doi.org/10.1172/JCI115711.
© 1992 The American Society for Clinical Investigation
Published April 1, 1992 - Version history
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Abstract

We found that a negative calcium-responsive element (nCaRE) originally reported in the human parathyroid hormone gene is conserved among several genes. The results of the present study show that expression of one of the genes, the rat atrial natriuretic polypeptide gene, was negatively regulated in the heart by extracellular calcium by using an in vivo infusion system. Moreover, transfection of the cultured cells revealed that this DNA element conferred negative regulation by extracellular calcium on the reporter gene. It is suggested that there is a gene family whose expression is negatively regulated by extracellular calcium through this conserved DNA motif, nCaRE.

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