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Research Article Free access | 10.1172/JCI115569

Gold-specific T cells in rheumatoid arthritis patients treated with gold.

P Romagnoli, G A Spinas, and F Sinigaglia

F. Hoffmann-La Roche Limited, Basel, Switzerland.

Find articles by Romagnoli, P. in: PubMed | Google Scholar

F. Hoffmann-La Roche Limited, Basel, Switzerland.

Find articles by Spinas, G. in: PubMed | Google Scholar

F. Hoffmann-La Roche Limited, Basel, Switzerland.

Find articles by Sinigaglia, F. in: PubMed | Google Scholar

Published January 1, 1992 - More info

Published in Volume 89, Issue 1 on January 1, 1992
J Clin Invest. 1992;89(1):254–258. https://doi.org/10.1172/JCI115569.
© 1992 The American Society for Clinical Investigation
Published January 1, 1992 - Version history
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Abstract

Gold-specific T lymphocyte clones were isolated from a patient with rheumatoid arthritis who developed delayed type hypersensitivity reactions to gold. All of the isolated T cell clones required histocompatible antigen presenting cells as well as gold for induction of proliferation. Using a panel of HLA-homozygous Epstein Barr virus-transformed B (EBV-B) cells and anti-HLA antibodies, the clones were shown to recognize gold in the context of DR1 molecules. Gold recognition did not require active antigen processing since specific proliferation was not affected by glutaraldehyde fixation of the DR1 homozygous antigen presenting cells. Furthermore, we could show that gold salts inhibited peptide-induced responses of a peptide-specific T cell clone. In addition to providing evidence for gold-specific T cells in gold-treated RA patients exhibiting delayed type hypersensitivity responses, these data suggest that gold can alter MHC-peptide complexes. The latter observation may in part explain the mechanism/s responsible for both the therapeutic and the toxic effects of gold.

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