A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus.

N Talal; R F Garry; P H Schur; S Alexander; M J Dauphinée; I H Livas; A Ballester; M Takei; H Dang

doi:10.1172/JCI114647

Clinical Immunology Section, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas 78284.

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Published in Volume 85, Issue 6 on June 1, 1990
J Clin Invest. 1990;85(6):1866–1871. https://doi.org/10.1172/JCI114647.
© 1990 The American Society for Clinical Investigation

Published June 1, 1990 - Version history

22 of 61 systemic lupus erythematosus (SLE) patients produced antibodies to the p24 gag protein of HIV-1 demonstrated by Western blotting. 20 of these 22 patients (91%) also express the 4B4 idiotype (Id 4B4) previously identified on a human anti-Sm monoclonal antibody called 4B4. This represents an enrichment for this Id (seen in only 52% of SLE patients generally). Eight of these 22 SLE patients also have anti-Sm antibody activity. Sm partially inhibits the antibody binding of p24 gag suggesting immunologic cross-reactivity between the retroviral antigen p24 gag and the autoantigen Sm. Anti-Id 4B4 also inhibits p24 gag antibody binding by as much as 40%. Finally the monoclonal antibody 4B4 showed cross-reactivity to Sm and p24 gag. The following points emerge from our studies: (a) SLE patients make antibodies to p24 gag of HIV-1, (b) there is a relationship between immunity to p24 gag and a conserved idiotype, and (c) anti-Sm antibodies can cross-react with p24 gag.

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A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus.

N Talal, R F Garry, P H Schur, S Alexander, M J Dauphinée, I H Livas, A Ballester, M Takei, and H Dang

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A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus.

N Talal, R F Garry, P H Schur, S Alexander, M J Dauphinée, I H Livas, A Ballester, M Takei, and H Dang

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