Advertisement

Research Article Free access | 10.1172/JCI114570

Endothelin messenger RNA and receptors are differentially expressed in cultured human breast epithelial and stromal cells.

P A Baley, T J Resink, U Eppenberger, and A W Hahn

Department of Research, Basel University Hospital, Switzerland.

Find articles by Baley, P. in: PubMed | Google Scholar

Department of Research, Basel University Hospital, Switzerland.

Find articles by Resink, T. in: PubMed | Google Scholar

Department of Research, Basel University Hospital, Switzerland.

Find articles by Eppenberger, U. in: PubMed | Google Scholar

Department of Research, Basel University Hospital, Switzerland.

Find articles by Hahn, A. in: PubMed | Google Scholar

Published April 1, 1990 - More info

Published in Volume 85, Issue 4 on April 1, 1990
J Clin Invest. 1990;85(4):1320–1323. https://doi.org/10.1172/JCI114570.
© 1990 The American Society for Clinical Investigation
Published April 1, 1990 - Version history
View PDF
Abstract

Paracrine regulation is implicit in the biosynthesis and secretion of milk in the breast. An important determinant for this regulation in vivo is proximate cellular location as exemplified by stromal and epithelial cells in breast tissue. Cultured human breast epithelial cells exhibited low constitutive expression of mRNA for endothelin which was enhanced 20-fold after prolactin stimulation. Human breast stromal cells did not express measurable levels of endothelin mRNA under similar conditions. In a similar differential manner, the stimulated release of immunoreactive endothelin into medium overlay was observed only for breast epithelial and not stromal cells. Specific cell-surface receptors for endothelin and biochemical responsiveness to the peptide were observed only in the stromal cells.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (April 1, 1990): No description
Advertisement
Advertisement