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Research Article Free access | 10.1172/JCI114549

Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor.

J R Williamson, E Ostrow, D Eades, K Chang, W Allison, C Kilo, and W R Sherman

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

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Published April 1, 1990 - More info

Published in Volume 85, Issue 4 on April 1, 1990
J Clin Invest. 1990;85(4):1167–1172. https://doi.org/10.1172/JCI114549.
© 1990 The American Society for Clinical Investigation
Published April 1, 1990 - Version history
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Abstract

Exposure of skin chamber granulation tissue vessels in nondiabetic rats to 11 or 15 mM D-glucose (but not L-glucose or 3-O-methylglucose) twice daily for 10 d induces vascular functional changes (increased albumin permeation and blood flow) identical to those in animals with mild or severe streptozotocin diabetes, respectively. These vascular changes are strongly linked to increased metabolism of glucose via the sorbitol pathway and are independent of nonenzymatic glycosylation as well as systemic metabolic and hormonal imbalances associated with the diabetic milieu. (J. Clin. Invest. 1990. 85:1167-1172.)

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