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Research Article Free access | 10.1172/JCI114222

Clustering of multiallele DNA markers near the Huntington's disease gene.

M E MacDonald, S V Cheng, M Zimmer, J L Haines, A Poustka, B Allitto, B Smith, W L Whaley, D M Romano, and J Jagadeesh

Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Boston 02114.

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Published September 1, 1989 - More info

Published in Volume 84, Issue 3 on September 1, 1989
J Clin Invest. 1989;84(3):1013–1016. https://doi.org/10.1172/JCI114222.
© 1989 The American Society for Clinical Investigation
Published September 1, 1989 - Version history
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Abstract

Five highly informative multiallele restriction fragment length polymorphisms (RFLPs) of value for preclinical diagnosis of Huntington's disease (HD) have been genetically characterized. One RFLP was uncovered by expansion of the D4S43 locus while three others are at D4S111 and D4S115, loci defined by NotI-linking clones. The final marker, D4S125, represents a recently discovered VNTR locus. All four loci map closer to the HD gene and to the telomere than D4S10, the original linked marker for HD. In combination with two multiallele RFLPs previously identified for D4S43 and another linked locus, D4S95, these five new multiallele markers will dramatically improve the speed and accuracy of predictive testing in HD, and increase its applicability by maximizing the chances of an informative test for anyone with appropriate family structure.

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