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Research Article Free access | 10.1172/JCI114016

Granulocyte-macrophage colony-stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes.

A Lindemann, D Riedel, W Oster, H W Ziegler-Heitbrock, R Mertelsmann, and F Herrmann

Department of Hematology, University of Mainz, Federal Republic of Germany.

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Department of Hematology, University of Mainz, Federal Republic of Germany.

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Department of Hematology, University of Mainz, Federal Republic of Germany.

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Department of Hematology, University of Mainz, Federal Republic of Germany.

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Department of Hematology, University of Mainz, Federal Republic of Germany.

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Department of Hematology, University of Mainz, Federal Republic of Germany.

Find articles by Herrmann, F. in: JCI | PubMed | Google Scholar

Published April 1, 1989 - More info

Published in Volume 83, Issue 4 on April 1, 1989
J Clin Invest. 1989;83(4):1308–1312. https://doi.org/10.1172/JCI114016.
© 1989 The American Society for Clinical Investigation
Published April 1, 1989 - Version history
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Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known as an inducer of proliferation and functional activation of myeloid cells. This study was carried out to characterize the effects of GM-CSF on polymorphonuclear leukocytes (PMN) more extensively. Using Northern blot analysis, we show that PMN are able to accumulate mRNAs for different cytokines, including tumor necrosis factor-alpha (TNF-alpha); G-CSF, and M-CSF, all of which are involved in inflammation and hematopoiesis. Biological assays and immunoassays demonstrate that PMN translate these mRNAs, except TNF-alpha, into secretory proteins. However, the expression of these cytokines is dependent on stimulation by exogenous signals, preferentially provided by the T cell-derived lymphokine GM-CSF. Stimulation of hematopoiesis and amplification of defense mechanisms after T cell activation thus might involve not only monocytes but also PMN, a cell type previously believed to be biosynthetically inactive.

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