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Research Article Free access | 10.1172/JCI113997

Influence of body fat distribution on free fatty acid metabolism in obesity.

M D Jensen, M W Haymond, R A Rizza, P E Cryer, and J M Miles

Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Jensen, M. in: PubMed | Google Scholar

Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905.

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Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Rizza, R. in: PubMed | Google Scholar

Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905.

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Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Miles, J. in: PubMed | Google Scholar

Published April 1, 1989 - More info

Published in Volume 83, Issue 4 on April 1, 1989
J Clin Invest. 1989;83(4):1168–1173. https://doi.org/10.1172/JCI113997.
© 1989 The American Society for Clinical Investigation
Published April 1, 1989 - Version history
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Abstract

In order to determine whether differences in body fat distribution result in specific abnormalities of free fatty acid (FFA) metabolism, palmitate turnover, a measure of systemic adipose tissue lipolysis, was measured in 10 women with upper body obesity, 9 women with lower body obesity, and 8 nonobese women under overnight postabsorptive (basal), epinephrine stimulated and insulin suppressed conditions. Results: Upper body obese women had greater (P less than 0.005) basal palmitate turnover than lower body obese or nonobese women (2.8 +/- 0.2 vs. 2.1 +/- 0.2 vs. 1.8 +/- 0.2 mumol.kg lean body mass (LBM)-1.min-1, respectively), but a reduced (P less than 0.05) net lipolytic response to epinephrine (59 +/- 7 vs. 79 +/- 5 vs. 81 +/- 7 mumol palmitate/kg LBM, respectively). Both types of obesity were associated with impaired suppression of FFA turnover in response to euglycemic hyperinsulinemia compared to nonobese women (P less than 0.005). These specific differences in FFA metabolism may reflect adipocyte heterogeneity, which may in turn affect the metabolic aberrations associated with different types of obesity. These findings emphasize the need to characterize obese subjects before studies.

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