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Research Article Free access | 10.1172/JCI113654

Developmental changes in the superoxide dismutase activity of human skin fibroblasts are maintained in vitro and are not caused by oxygen.

R G Allen and A K Balin

Laboratory for Investigative Dermatology, Rockefeller University, New York 10021.

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Laboratory for Investigative Dermatology, Rockefeller University, New York 10021.

Find articles by Balin, A. in: JCI | PubMed | Google Scholar

Published August 1, 1988 - More info

Published in Volume 82, Issue 2 on August 1, 1988
J Clin Invest. 1988;82(2):731–734. https://doi.org/10.1172/JCI113654.
© 1988 The American Society for Clinical Investigation
Published August 1, 1988 - Version history
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Abstract

Confluent cultures of human skin fibroblast lines established from fetal and postnatal donors were exposed to a broad range of oxygen tensions (10-600 mmHg) for 1 wk; superoxide dismutase (SOD) activity was subsequently determined. Hyperoxia increased SOD activity slightly in postnatal lines but not in fetal lines. The magnitude of the increase in postnatal lines was not significant. Fetal lines exhibit only about one-fifth the SOD activity observed in postnatal lines. The results indicate that, while development-associated changes in SOD do occur in human cells, these alterations do not result from variations in ambient oxygen tension.

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