Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

G Suárez; R Rajaram; K C Bhuyan; A L Oronsky; J A Goidl

doi:10.1172/JCI113641

Published August 1, 1988 - More info

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Abstract

As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the fluorescence related to advanced Maillard products in their skin collagen. This effect is consistent with the in vivo occurrence of nonenzymatic fructosylation of collagen. A potential pathogenetic role for this posttranslational modification in diabetic complications should be considered.

Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

G Suárez, R Rajaram, K C Bhuyan, A L Oronsky, and J A Goidl

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Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

G Suárez, R Rajaram, K C Bhuyan, A L Oronsky, and J A Goidl

Article tools

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