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Research Article Free access | 10.1172/JCI113595

Identification of the C5a des Arg cochemotaxin. Homology with vitamin D-binding protein (group-specific component globulin).

H D Perez, E Kelly, D Chenoweth, and F Elfman

Rosalind Russell Arthritis Research Laboratory, University of California, San Francisco 94143.

Find articles by Perez, H. in: PubMed | Google Scholar

Rosalind Russell Arthritis Research Laboratory, University of California, San Francisco 94143.

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Rosalind Russell Arthritis Research Laboratory, University of California, San Francisco 94143.

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Rosalind Russell Arthritis Research Laboratory, University of California, San Francisco 94143.

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Published July 1, 1988 - More info

Published in Volume 82, Issue 1 on July 1, 1988
J Clin Invest. 1988;82(1):360–363. https://doi.org/10.1172/JCI113595.
© 1988 The American Society for Clinical Investigation
Published July 1, 1988 - Version history
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Abstract

The chemotactic activity of human C5a des Arg is enhanced significantly by an anionic polypeptide (cochemotaxin) in normal human serum and plasma. The cochemotaxin attaches to sialic acid residues within the oligosaccharide chain of native C5a des Arg to form a complex with potent chemotactic activity for human PMN. We investigated the nature of the cochemotaxin and found that vitamin D-binding protein is the putative cochemotaxin. Vitamin D-binding protein enhanced the chemotactic activity of native C5a des Arg, but had no effect on the chemotactic activity of either native C5a or FMLP. Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography. Furthermore, vitamin D-binding protein and cochemotaxin exhibited identical molecular weights, isoelectric points, antigenic reactivity, and amino acid composition.

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