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Research Article Free access | 10.1172/JCI113531

SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.

B F Murphy, L Kirszbaum, I D Walker, and A J d'Apice

Department of Nephrology, Royal Melbourne Hospital, Australia.

Find articles by Murphy, B. in: PubMed | Google Scholar

Department of Nephrology, Royal Melbourne Hospital, Australia.

Find articles by Kirszbaum, L. in: PubMed | Google Scholar

Department of Nephrology, Royal Melbourne Hospital, Australia.

Find articles by Walker, I. in: PubMed | Google Scholar

Department of Nephrology, Royal Melbourne Hospital, Australia.

Find articles by d'Apice, A. in: PubMed | Google Scholar

Published June 1, 1988 - More info

Published in Volume 81, Issue 6 on June 1, 1988
J Clin Invest. 1988;81(6):1858–1864. https://doi.org/10.1172/JCI113531.
© 1988 The American Society for Clinical Investigation
Published June 1, 1988 - Version history
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Abstract

We report herein the isolation and initial characterization of a novel protein, termed SP-40,40, which is present at moderate levels (35-105 micrograms/ml) in normal human serum. SP-40,40 is deposited in the renal glomeruli of patients with glomerulonephritis but is not found in normal glomeruli. The protein is a heterodimeric structure of relative molecular mass 80 kD, both chains of which are of a similar size (40 kD). The amino-terminal sequences of both chains are unrelated to one another and possess no significant homology to any known protein sequence. The tissue distribution of SP-40,40 closely resembles that of the terminal complement components and its physicochemical properties are similar to, but distinct from, those of the S protein of complement. We have identified SP-40,40 in the SC5b-9 complex of complement and have demonstrated incorporation of labeled SP-40,40 into this complex. These data suggest that SP-40,40 is an additional component of SC5b-9.

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