Molecular analysis of a variant type of familial amyloidotic polyneuropathy showing cerebellar ataxia and pyramidal tract signs.

H Furuya; K Yoshioka; H Sasaki; Y Sakaki; M Nakazato; H Matsuo; A Nakadai; S Ikeda; N Yanagisawa

doi:10.1172/JCI113261

Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.

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Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.

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Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.

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Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.

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Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.

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Published in Volume 80, Issue 6 on December 1, 1987
J Clin Invest. 1987;80(6):1706–1711. https://doi.org/10.1172/JCI113261.
© 1987 The American Society for Clinical Investigation

Published December 1, 1987 - Version history

A Japanese family with atypical type I familial amyloidotic polyneuropathy (FAP) in Iiyama, Japan was studied. Most of the family members have dysfunctions in the central nervous system, in addition to typical symptoms of type I FAP. The transthyretin (TTR, also called prealbumin) gene of the atypical FAP(FAP-IY) was analyzed with recombinant DNA techniques and a RIA method. FAP-IY was found to have the mutation responsible for the methionine-for-valine substitution at position 30 of TTR, as in the case of typical type I FAP. However, analysis of DNA polymorphisms in the TTR locus showed that FAP-IY has a genetic background differing from that of the typical type I FAP. These observations lead to the consideration that a genetic factor(s) involved in the dysfunction of the central nervous system may locate in a chromosome region in close proximity to the TTR gene.

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Molecular analysis of a variant type of familial amyloidotic polyneuropathy showing cerebellar ataxia and pyramidal tract signs.

H Furuya, K Yoshioka, H Sasaki, Y Sakaki, M Nakazato, H Matsuo, A Nakadai, S Ikeda, and N Yanagisawa

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Molecular analysis of a variant type of familial amyloidotic polyneuropathy showing cerebellar ataxia and pyramidal tract signs.

H Furuya, K Yoshioka, H Sasaki, Y Sakaki, M Nakazato, H Matsuo, A Nakadai, S Ikeda, and N Yanagisawa

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