A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.

C Morimoto; A D Steinberg; N L Letvin; M Hagan; T Takeuchi; J Daley; H Levine; S F Schlossman

doi:10.1172/JCI112882

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Published in Volume 79, Issue 3 on March 1, 1987
J Clin Invest. 1987;79(3):762–768. https://doi.org/10.1172/JCI112882.
© 1987 The American Society for Clinical Investigation

Published March 1, 1987 - Version history

The cell surface phenotype of peripheral blood lymphocytes (PBL) of systemic lupus erythematosus (SLE) patients was characterized with the anti-2H4 monoclonal antibody that defines the human suppressor inducer subset. The T4+2H4+ population of cells has been shown to be critical for the activation of T8+ suppressor cells. Patients with SLE has a markedly decreased percentage of T4+2H4+ cells (13 +/- 2%) in their PBL compared with normal controls (21 +/- 1%) (P less than 0.001). This reduction was greatest in patients with active SLE, especially those with renal disease. Serial analysis of patients with SLE and renal disease showed a correlation between percent positive circulating T4+2H4+ cells and disease activity. Moreover, there was a significant correlation between a low percentage of T4+2H4+ cells and decreased suppressor-inducer function in autologous mixed lymphocyte reaction-activated T4+ cells from SLE patients. Thus, a deficiency exists in SLE patients with active renal disease in the T4+2H4+ suppressor-inducer T cell subset.

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A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.

C Morimoto, A D Steinberg, N L Letvin, M Hagan, T Takeuchi, J Daley, H Levine, and S F Schlossman

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A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.

C Morimoto, A D Steinberg, N L Letvin, M Hagan, T Takeuchi, J Daley, H Levine, and S F Schlossman

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