A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.

N Kawamura; A Muraguchi; A Hori; Y Horii; S Mutsuura; R R Hardy; H Kikutani; T Kishimoto

doi:10.1172/JCI112719

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A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.

N Kawamura, A Muraguchi, A Hori, Y Horii, S Mutsuura, R R Hardy, H Kikutani, and T Kishimoto

Published November 1, 1986 - More info

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Abstract

Production of B cell growth factor (BCGF) from B-chronic lymphocytic leukemia (B-CLL) cells was demonstrated. Freshly isolated monoclonal B-CLL cells expressed surface mu, delta, B1, and Leu 1, but not Ba (an antigen expressed only on activated B cells). Upon stimulation with anti-IgM, they secreted BCGF, which could act on anti-IgM-stimulated autologous leukemic cells as well as anti-IgM-stimulated normal B cells. Cell lines established from these leukemic cells also constitutively secreted BCGF. The BCGF from B-CLL cells or established cell lines induced neither proliferation nor enhanced HLA-DR expression in resting B cells. These results show the presence of B cell-derived BCGF, which is distinct from BSF-1 and effective only on activated B cells. They also suggest that an autocrine mechanism may operate in the growth of B-CLL cells.

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A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.

N Kawamura, A Muraguchi, A Hori, Y Horii, S Mutsuura, R R Hardy, H Kikutani, and T Kishimoto

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A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.

N Kawamura, A Muraguchi, A Hori, Y Horii, S Mutsuura, R R Hardy, H Kikutani, and T Kishimoto

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