Advertisement
Research Article Free access | 10.1172/JCI112719
Find articles by Kawamura, N. in: JCI | PubMed | Google Scholar
Find articles by Muraguchi, A. in: JCI | PubMed | Google Scholar
Find articles by Hori, A. in: JCI | PubMed | Google Scholar
Find articles by Horii, Y. in: JCI | PubMed | Google Scholar
Find articles by Mutsuura, S. in: JCI | PubMed | Google Scholar
Find articles by Hardy, R. in: JCI | PubMed | Google Scholar
Find articles by Kikutani, H. in: JCI | PubMed | Google Scholar
Find articles by Kishimoto, T. in: JCI | PubMed | Google Scholar
Published November 1, 1986 - More info
Production of B cell growth factor (BCGF) from B-chronic lymphocytic leukemia (B-CLL) cells was demonstrated. Freshly isolated monoclonal B-CLL cells expressed surface mu, delta, B1, and Leu 1, but not Ba (an antigen expressed only on activated B cells). Upon stimulation with anti-IgM, they secreted BCGF, which could act on anti-IgM-stimulated autologous leukemic cells as well as anti-IgM-stimulated normal B cells. Cell lines established from these leukemic cells also constitutively secreted BCGF. The BCGF from B-CLL cells or established cell lines induced neither proliferation nor enhanced HLA-DR expression in resting B cells. These results show the presence of B cell-derived BCGF, which is distinct from BSF-1 and effective only on activated B cells. They also suggest that an autocrine mechanism may operate in the growth of B-CLL cells.
Images.