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Research Article Free access | 10.1172/JCI112357

Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.

T Takeuchi, D L Gumucio, T Yamada, M H Meisler, C D Minth, J E Dixon, R E Eddy, and T B Shows

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Published March 1, 1986 - More info

Published in Volume 77, Issue 3 on March 1, 1986
J Clin Invest. 1986;77(3):1038–1041. https://doi.org/10.1172/JCI112357.
© 1986 The American Society for Clinical Investigation
Published March 1, 1986 - Version history
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Abstract

Pancreatic polypeptide and neuropeptide Y share 50% amino acid homology (18 out of 36 residues), suggesting that they may have common ancestral origins. cDNA clones complementary to human mRNAs encoding pancreatic polypeptide and neuropeptide Y were used to detect specific human genomic DNA sequences in human-mouse somatic cell hybrid lines. The pancreatic polypeptide gene (PPY) segregated with human chromosome 17, while the neuropeptide Y gene (NPY) segregated with human chromosome 7. Examination of cell hybrids with chromosomal rearrangements assigned PPY to the p11.1-qter region and NPY to the pter-q22 region of their respective chromosomes.

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