Advertisement

Research Article Free access | 10.1172/JCI111881

Immunization with a Plasmodium falciparum merozoite surface antigen induces a partial immunity in monkeys.

L H Perrin, B Merkli, M S Gabra, J W Stocker, C Chizzolini, and R Richle

Find articles by Perrin, L. in: PubMed | Google Scholar

Find articles by Merkli, B. in: PubMed | Google Scholar

Find articles by Gabra, M. in: PubMed | Google Scholar

Find articles by Stocker, J. in: PubMed | Google Scholar

Find articles by Chizzolini, C. in: PubMed | Google Scholar

Find articles by Richle, R. in: PubMed | Google Scholar

Published May 1, 1985 - More info

Published in Volume 75, Issue 5 on May 1, 1985
J Clin Invest. 1985;75(5):1718–1721. https://doi.org/10.1172/JCI111881.
© 1985 The American Society for Clinical Investigation
Published May 1, 1985 - Version history
View PDF
Abstract

Saimiri monkeys immunized with a Plasmodium falciparum merozoite polypeptide of 41 kD mol wt are resistant to a blood challenge infection that induces a fulminant infection in control monkeys. The sera of the immunized monkeys reacted, as shown by the indirect immunofluorescence technique, with the apical part of the merozoites from five isolates or clones of P. falciparum. Whether the immunogen was dissolved in nonionic detergent (NP-40) or in sodium dodecyl sulfate (SDS) had a marked influence on the level of protection in immunized monkeys. Thus, monkeys immunized with the antigen solubilized in a nonionic detergent developed much lower parasitemia than monkeys immunized with denatured antigen (antigen eluted from SDS polyacrylamide gel electrophoresis).

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (May 1, 1985): No description
Advertisement
Advertisement