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Research Article Free access | 10.1172/JCI111771

T cells and probably B cells arise from the malignant clone in chronic myelogenous leukemia.

A A Fauser, L Kanz, K J Bross, and G W Löhr

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Published March 1, 1985 - More info

Published in Volume 75, Issue 3 on March 1, 1985
J Clin Invest. 1985;75(3):1080–1082. https://doi.org/10.1172/JCI111771.
© 1985 The American Society for Clinical Investigation
Published March 1, 1985 - Version history
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Abstract

Bone marrow cells from a patient with Ph' positive chronic myelogenous leukemia in chronic phase were cultured for multilineage hematopoietic colonies (CFU-GEMMT), erythroid bursts, and granulocytic colonies. With CFU-GEMMT colonies, T lymphocytes were identified by reaction with monoclonal antibodies Leu-5 and OKT-3; B cells were identified by reaction with B1. All CFU-GEMMT colonies examined contained the Ph' chromosome. Recloned secondary colonies of T cells reacted with Leu-5 and OKT-3 and were Ph' positive. This demonstrates that Ph' positive T lymphocytes were generated from the pluripotential stem cell of this patient. The presence of B cells in the mixed colonies indicates that these may also be derived from the neoplastic clone.

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