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Usage Information

Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis.
B S Nepom, … , P Antonelli, J A Hansen
B S Nepom, … , P Antonelli, J A Hansen
Published July 1, 1984
Citation Information: J Clin Invest. 1984;74(1):287-291. https://doi.org/10.1172/JCI111413.
View: Text | PDF
Research Article

Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis.

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Abstract

The structural and functional heterogeneity of HLA-DR4-associated specificities was investigated in patients with seropositive juvenile rheumatoid arthritis, a DR4-associated disease. Using a combination of HLA-D analysis by mixed lymphocyte culture and electrophoretic analysis of immunoprecipitated Ia molecules by two-dimensional polyacrylamide gels, we observed a surprisingly homogeneous pattern of HLA-D antigen expression. All patients expressed common structural products of the DR and DS loci, and 7/12 homozygous DR4 patients expressed a rare and subtle HLA-D heterozygous phenotype.

Authors

B S Nepom, G T Nepom, E Mickelson, J G Schaller, P Antonelli, J A Hansen

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