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Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.
S J Wassner, … , A Sperduto, M E Norman
S J Wassner, … , A Sperduto, M E Norman
Published July 1, 1983
Citation Information: J Clin Invest. 1983;72(1):102-112. https://doi.org/10.1172/JCI110947.
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Research Article

Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

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Abstract

The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained be feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.

Authors

S J Wassner, J B Li, A Sperduto, M E Norman

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