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Usage Information

Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN
Y. Antero Kesaniemi, Joseph L. Witztum, Urs P. Steinbrecher
Y. Antero Kesaniemi, Joseph L. Witztum, Urs P. Steinbrecher
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Research Article

Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN

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Abstract

Low density lipoprotein (LDL) catabolism occurs by LDL receptor-dependent and LDL receptor-independent pathways. We have shown previously that nonenzymatic glucosylation of LDL in the presence of cyanoborohydride irreversibly blocks the lysine residues of LDL. Glucosylated LDL (GLC-LDL) was not degraded by the LDL receptor of fibroblasts, and its degradation by macrophages was similar to that of native LDL. This suggested that GLC-LDL should be a good tracer of LDL receptor-independent catabolism, and if combined with a tracer of total LDL catabolism, should enable one to calculate the extent of LDL receptor-dependent catabolism.

Authors

Y. Antero Kesaniemi, Joseph L. Witztum, Urs P. Steinbrecher

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 334 14
PDF 122 10
Scanned page 688 0
Citation downloads 149 0
Totals 1,293 24
Total Views 1,317
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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