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Research Article Free access | 10.1172/JCI110733

Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase.

J D Tissot, P Schneider, J Hauert, M Ruegg, E K Kruithof, and F Bachmann

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Published December 1, 1982 - More info

Published in Volume 70, Issue 6 on December 1, 1982
J Clin Invest. 1982;70(6):1320–1323. https://doi.org/10.1172/JCI110733.
© 1982 The American Society for Clinical Investigation
Published December 1, 1982 - Version history
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Abstract

Two different plasmatic plasminogen activators (PA) can be demonstrated after sodium dodecyl sulfate polyacrylamide gel electrophoresis of plasma freshly collected from resting volunteers, followed by transfer of the gels onto plasminogen-rich fibrin-agarose plates. These two PA are also present in plasmas deficient in coagulation Factor XI, Factor XII, prekallikrein, or high molecular weight-kininogen. The slower-moving PA has an apparent 85,000 Mr and is immunologically unrelated to urokinase (UK). The faster moving PA was isolated by immunoadsorption of plasma on anti-UK IgG coupled to Sepharose 4B and appears to be identical to urinary high molecular weight-UK.

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