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Research Article Free access | 10.1172/JCI110599

Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts.

B Borgström and C Erlanson-Albertsson

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Published July 1, 1982 - More info

Published in Volume 70, Issue 1 on July 1, 1982
J Clin Invest. 1982;70(1):30–32. https://doi.org/10.1172/JCI110599.
© 1982 The American Society for Clinical Investigation
Published July 1, 1982 - Version history
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Abstract

Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts. This is contrary to a recent report in this Journal (J. Clin. Invest. 67: 1748-1752.) according to which inhibition of lipase by bile salt could be overcome by the addition of colipase or phospholipase A2. This latter finding is shown to be due to contamination of commercially available pancreatic phospholipase A2 by colipase.

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