Immunoglobulin E-rheumatoid factor in the serum of patients with rheumatoid arthritis, asthma, and other diseases.

B L Zuraw; C H O'Hair; J H Vaughan; D A Mathison; J G Curd; D H Katz

doi:10.1172/JCI110418

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Immunoglobulin E-rheumatoid factor in the serum of patients with rheumatoid arthritis, asthma, and other diseases.

B L Zuraw, C H O'Hair, J H Vaughan, D A Mathison, J G Curd, and D H Katz

Published December 1, 1981 - More info

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Abstract

A solid-phase radioimmunoassay was developed to detect immunoglobulin (Ig)E antibodies that bound to human IgG. IgE-rheumatoid factor activity was found in the serum of 18 of 20 patients with seropositive rheumatoid arthritis, 1 of 4 patients with seronegative rheumatoid arthritis, 3 of 32 patients with seronegative rheumatoid arthritis, 3 of 32 patients with asthma, and in 1 patient with hypocomplementemic vasculitis and iodide sensitivity. Immunopathologic implications of IgE-rheumatoid factor are discussed.

Immunoglobulin E-rheumatoid factor in the serum of patients with rheumatoid arthritis, asthma, and other diseases.

B L Zuraw, C H O'Hair, J H Vaughan, D A Mathison, J G Curd, and D H Katz

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Immunoglobulin E-rheumatoid factor in the serum of patients with rheumatoid arthritis, asthma, and other diseases.

B L Zuraw, C H O'Hair, J H Vaughan, D A Mathison, J G Curd, and D H Katz

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