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Research Article Free access | 10.1172/JCI110335

Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.

T Wasada, K McCorkle, V Harris, K Kawai, B Howard, and R H Unger

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Published October 1, 1981 - More info

Published in Volume 68, Issue 4 on October 1, 1981
J Clin Invest. 1981;68(4):1106–1107. https://doi.org/10.1172/JCI110335.
© 1981 The American Society for Clinical Investigation
Published October 1, 1981 - Version history
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Abstract

To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.

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