Splanchnic Metabolism of Plasma Apolipoprotein B: STUDIES OF ARTERY-HEPATIC VEIN DIFFERENCES OF MASS AND RADIOLABEL IN FASTED HUMAN SUBJECTS
P. R. Turner, N. E. Miller, C. Cortese, W. Hazzard, J. Coltart, B. Lewis
P. R. Turner, N. E. Miller, C. Cortese, W. Hazzard, J. Coltart, B. Lewis
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Splanchnic Metabolism of Plasma Apolipoprotein B: STUDIES OF ARTERY-HEPATIC VEIN DIFFERENCES OF MASS AND RADIOLABEL IN FASTED HUMAN SUBJECTS

Abstract

The metabolism of apoprotein B-containing plasma lipoproteins by human splanchnic tissues has been studied in 29 men undergoing coronary angiography. Before catheterization autologous radio-iodinated lipoproteins were infused into a peripheral vein: 10 subjects received 125I-labeled Sf 12-60 lipoproteins; 12 received 125I-labeled Sf 12-60 plus 131I-labeled Sf 100-400 lipoproteins; and 7 received 125I-labeled Sf 12-60 plus 131I-labeled Sf 0-12 lipoproteins. Paired arterial and hepatic vein blood samples were subsequently collected for replicate measurements of apoprotein B (apo B) mass, radioactivity and specific activity in each lipoprotein class. Splanchnic plasma flow was measured with indocyanine green. All studies were conducted after a 14-h overnight fast.

Authors

P. R. Turner, N. E. Miller, C. Cortese, W. Hazzard, J. Coltart, B. Lewis

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