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Research Article Free access | 10.1172/JCI110143

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

S Gillis, R Kozak, M Durante, and M E Weksler

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Published April 1, 1981 - More info

Published in Volume 67, Issue 4 on April 1, 1981
J Clin Invest. 1981;67(4):937–942. https://doi.org/10.1172/JCI110143.
© 1981 The American Society for Clinical Investigation
Published April 1, 1981 - Version history
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Abstract

Human lymphocytes from elderly and young donors were cultured with phytohemagglutinin (PHA) or concanavalin A. Cultures from old donors produced less T cell growth factor (TCGF) and incorporated less tritiated thymidine (3H-Tdr) than did similar cultures from young donors in the presence of either mitogen. Furthermore, the response of lymphocytes from elderly donors to TCGF was impaired. Thus, PHA-activated T cells from aged donors showed no increase tritiated thymidine incorporation when incubated with exogenous human TCGF. In contrast, addition of exogenous human TCGF to PHA-activated peripheral blood leukocytes from younger individuals increased tritiated thymidine incorporation by 30-50%. The impaired response to TCGF was associated with decreased binding of TCGF by PHA-activated cells from old donors. TCGF production or responsiveness was not associated with the presence of "suppressor" activity in elderly T cell preparations. These studies suggest a possible molecular mechanism for the impaired proliferative response of elderly human T cells. These data lend support to the hypothesis that defects in the capacity to either produce or respond to TCGF may be a fundamental cause of immune deficiency.

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