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Research Article Free access | 10.1172/JCI110031

Antihelper T cell autoantibody in acquired agammaglobulinemia.

A Rubinstein, M Sicklick, V Mehra, F S Rosen, and R H Levey

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Published January 1, 1981 - More info

Published in Volume 67, Issue 1 on January 1, 1981
J Clin Invest. 1981;67(1):42–50. https://doi.org/10.1172/JCI110031.
© 1981 The American Society for Clinical Investigation
Published January 1, 1981 - Version history
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Abstract

A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH2- T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH2+Ia+ T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cells. Conversely, total thymectomy resulted in a temporary disappearance of the TH2+Ia+ suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.

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