Comparison of Human Eosinophils from Normals and Patients with Eosinophilia

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Abstract

Previous studies of the biochemistry and physiology of eosinophils have relied upon cells obtained from patients with eosinophilia (EE). It is unknown whether such cells might have been activated or partially exhausted by the pathological state causing eosinophilia. We examined cell surface charge, membrane transport of deoxyglucose, activation of lyso-somal acid phosphatase, and oxidative metabolism to provide a profile to compare EE with purified normal eosinophils (NE) and normal neutrophils.

Authors

David A. Bass, William H. Grover, Jon C. Lewis, Pamela Szejda, Lawrence R. DeChatelet, Charles E. McCall