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Usage Information

Turnover of Lipoprotein (a) in Man
Franz Krempler, … , Klaus Bolzano, Friedrich Sandhofer
Franz Krempler, … , Klaus Bolzano, Friedrich Sandhofer
Published June 1, 1980
Citation Information: J Clin Invest. 1980;65(6):1483-1490. https://doi.org/10.1172/JCI109813.
View: Text | PDF
Research Article

Turnover of Lipoprotein (a) in Man

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Abstract

An elevated concentration of lipoprotein (a) [Lp(a)] in the serum has been considered a risk factor for coronary heart disease by various investigators. In the present study, the turnover of Lp(a) was investigated in nine individuals with serum Lp(a) levels ranging from 1 to 68 mg/100 ml. After intravenous injection of radioiodinated Lp(a), the radioactivity time-curve of the serum and the specific activitity time-curves of the isolated Lp(a) and Lp(a) apolipoproteins were measured for 14 d. More than 97% of the label was found in the protein moiety of Lp(a). During the entire study period, the serum radioactivity remained with Lp(a), only insignificant amounts of radioactivity were detectable in other lipoprotein fractions. The serum radioactivity time-curves and the specific activity time-curves of the isolated Lp(a) and Lp(a) apolipoproteins were identical.

Authors

Franz Krempler, Gerhard M. Kostner, Klaus Bolzano, Friedrich Sandhofer

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 185 54
PDF 76 53
Scanned page 312 9
Citation downloads 60 0
Totals 633 116
Total Views 749
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