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Research Article Free access | 10.1172/JCI109813

Turnover of Lipoprotein (a) in Man

Franz Krempler, Gerhard M. Kostner, Klaus Bolzano, and Friedrich Sandhofer

First Department of Medicine, Landeskrankenanstalten, A-5020 Salzburg, Austria

Institute of Medical Biochemistry, University of Graz, A-8010 Graz, Austria

Find articles by Krempler, F. in: PubMed | Google Scholar

First Department of Medicine, Landeskrankenanstalten, A-5020 Salzburg, Austria

Institute of Medical Biochemistry, University of Graz, A-8010 Graz, Austria

Find articles by Kostner, G. in: PubMed | Google Scholar

First Department of Medicine, Landeskrankenanstalten, A-5020 Salzburg, Austria

Institute of Medical Biochemistry, University of Graz, A-8010 Graz, Austria

Find articles by Bolzano, K. in: PubMed | Google Scholar

First Department of Medicine, Landeskrankenanstalten, A-5020 Salzburg, Austria

Institute of Medical Biochemistry, University of Graz, A-8010 Graz, Austria

Find articles by Sandhofer, F. in: PubMed | Google Scholar

Published June 1, 1980 - More info

Published in Volume 65, Issue 6 on June 1, 1980
J Clin Invest. 1980;65(6):1483–1490. https://doi.org/10.1172/JCI109813.
© 1980 The American Society for Clinical Investigation
Published June 1, 1980 - Version history
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Abstract

An elevated concentration of lipoprotein (a) [Lp(a)] in the serum has been considered a risk factor for coronary heart disease by various investigators. In the present study, the turnover of Lp(a) was investigated in nine individuals with serum Lp(a) levels ranging from 1 to 68 mg/100 ml. After intravenous injection of radioiodinated Lp(a), the radioactivity time-curve of the serum and the specific activitity time-curves of the isolated Lp(a) and Lp(a) apolipoproteins were measured for 14 d. More than 97% of the label was found in the protein moiety of Lp(a). During the entire study period, the serum radioactivity remained with Lp(a), only insignificant amounts of radioactivity were detectable in other lipoprotein fractions. The serum radioactivity time-curves and the specific activity time-curves of the isolated Lp(a) and Lp(a) apolipoproteins were identical.

The kinetic parameters of Lp(a) turnover were calculated in terms of a two-compartment model. 76.5±5.1% (mean±1 SD) of total Lp(a) was contained in the intravascular space. The biological half-life of Lp(a) was 3.32±0.52 d, the fractional catabolic rate (FCR) was 0.306±0.054/d, and the rate of synthesis was 5.00±3.37 mg/kg/d. A positive correlation was found between serum concentration and synthetic rate of Lp(a) apoprotein. No relationship could be demonstrated between serum level and FCR of Lp(a).

The results of this study indicate that Lp(a) is not converted to other serum lipoproteins. From the correlations between serum concentration and kinetic parameters of Lp(a) it is concluded that an elevated Lp(a) level is the consequence of an increased Lp(a) apoprotein synthesis.

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