Increased calcium (Ca) excretion is characteristic of chronic phosphate (PO4) depletion (PD). To study the changes in tubular transport and the site of the hypocalciuric effect of PO4 administration, clearance and micropuncture experiments were performed in intact rats pair fed either a control diet (0.5% PO4) or a PO4-depleted (PD) diet (0.01% PO4) plus Al(OH3) and in parathyroidectomized (PTX) PD rats, infused either with saline or with neutral sodium PO4.
Authors
Kai Lau, Zalman S. Agus, Martin Goldberg, Stanley Goldfarb
