Advertisement
Research Article Free access | 10.1172/JCI109535
Find articles by Orkin, S. in: JCI | PubMed | Google Scholar
Find articles by Alter, B. in: JCI | PubMed | Google Scholar
Find articles by Altay, C. in: JCI | PubMed | Google Scholar
Published September 1, 1979 - More info
In an individual homozygous for G gamma-delta beta-thalassemia, a physical alteration in gamma-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A gamma-globin chains resulted from extension of the DNA deletion from the delta beta-globin gene region into the gamma-globin gene region rather than a functional disturbance of gamma-gene expression.
Images.
Click on an image below to see the page. View PDF of the complete article