Adrenergic Modulation of Pancreatic A, B, and D Cells: α-ADRENERGIC SUPPRESSION AND β-ADRENERGIC STIMULATION OF SOMATOSTATIN SECRETION, α-ADRENERGIC STIMULATION OF GLUCAGON SECRETION IN THE PERFUSED DOG PANCREAS

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Abstract

The effects of adrenergic substances on pancreatic insular secretions were studied in a completely isolated canine pancreas with exclusion of the duodenum from the perfusion circuit. To ensure adequate blockade, blockers were infused before agonists. A dose range of β-receptor blockade was tested, and putative α-adrenergic effects were confirmed by combined α- and β-adrenergic receptor blockade.

Authors

Ellis Samols, Gordon C. Weir