Advertisement

Research Article Free access | 10.1172/JCI109272

Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet.

R Pick, J Chediak, and G Glick

Find articles by Pick, R. in: PubMed | Google Scholar

Find articles by Chediak, J. in: PubMed | Google Scholar

Find articles by Glick, G. in: PubMed | Google Scholar

Published January 1, 1979 - More info

Published in Volume 63, Issue 1 on January 1, 1979
J Clin Invest. 1979;63(1):158–162. https://doi.org/10.1172/JCI109272.
© 1979 The American Society for Clinical Investigation
Published January 1, 1979 - Version history
View PDF
Abstract

The effect of aspirin in the primary prevention of diet-induced atherogenesis in cynomolgus monkeys was studied. The diet consisted of 2% cholesterol and 10% butter by weight for 24 wk. Six monkeys received only the atherogenic diet and five monkeys received the diet plus aspirin, 81 mg/monkey per day. Aspirin did not affect plasma cholesterol levels or aortic atherosclerosis. Platelet aggregation to arachidonic acid was almost completely suppressed. Aspirin decreased significantly the number of coronary vessels with atherosclerotic involvement, and the number of coronary vessels narrowed by 20% or more. Thus, aspirin appears to exert a protective effect in the primary prevention of diet-induced coronary atherosclerosis in a primate model.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (January 1, 1979): No description
Advertisement
Advertisement