Resistance to Arteriosclerosis in Pigs with von Willebrand's Disease: SPONTANEOUS AND HIGH CHOLESTEROL DIET-INDUCED ARTERIOSCLEROSIS

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Abstract

The aortas of 11 pigs (aged 1-3 yr) with homozygous von Willebrand's disease (vWd) were compared with those of 11 normal pigs of the same ages. Six of the controls exhibited multiple arteriosclerotic plaques with intimal thickening of 63-130 μm. In contrast, none of the pigs with vWd had multiple plaques, and only one had a lesion >2 mm in diameter.

Authors

Valentin Fuster, E. J. Walter Bowie, Jon C. Lewis, David N. Fass, Charles A. Owen Jr., Arnold L. Brown