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Usage Information

Decreased Fluidity of Red Cell Membrane Lipids in Abetalipoproteinemia
Richard A. Cooper, … , John R. Durocher, Mary H. Leslie
Richard A. Cooper, … , John R. Durocher, Mary H. Leslie
Published July 1, 1977
Citation Information: J Clin Invest. 1977;60(1):115-121. https://doi.org/10.1172/JCI108747.
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Research Article

Decreased Fluidity of Red Cell Membrane Lipids in Abetalipoproteinemia

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Abstract

Acanthocytic red cells in patients with abetalipoproteinemia are morphologically similar to the red cells in spur cell anemia. Fluidity of membrane lipids is decreased in spur cells due to their excess cholesterol content. Acanthocyte membranes have an increased content of sphingomyelin and a decreased content of lecithin. To assess the effect of this abnormality of acanthocyte membrane lipid composition on membrane fluidity, we studied red cells from five patients with abetalipoproteinemia and four obligate heterozygote family members.

Authors

Richard A. Cooper, John R. Durocher, Mary H. Leslie

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 284 57
PDF 73 13
Scanned page 329 10
Citation downloads 72 0
Totals 758 80
Total Views 838
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