Richard A. Cooper, … , John R. Durocher, Mary H. Leslie
Citation Information: J Clin Invest. 1977;60(1):115-121. https://doi.org/10.1172/JCI108747.
Richard A. Cooper, … , John R. Durocher, Mary H. Leslie
Published July 1, 1977
Citation Information: J Clin Invest. 1977;60(1):115-121. https://doi.org/10.1172/JCI108747.
Abstract
Acanthocytic red cells in patients with abetalipoproteinemia are morphologically similar to the red cells in spur cell anemia. Fluidity of membrane lipids is decreased in spur cells due to their excess cholesterol content. Acanthocyte membranes have an increased content of sphingomyelin and a decreased content of lecithin. To assess the effect of this abnormality of acanthocyte membrane lipid composition on membrane fluidity, we studied red cells from five patients with abetalipoproteinemia and four obligate heterozygote family members.
Authors
Richard A. Cooper, John R. Durocher, Mary H. Leslie
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